Next-generation approaches to understand and combat the antibiotic resistome

Sampling the antibiotic resistome.

Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a r...

The next generation of combat casualty care.

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Synthetic Biology Approaches to Combat Antibiotic Resistant Bacteria

Synthetic biology (SB) is an innovative and emerging field, representing a confluence of science and engineering. It aims to (re)-design biological parts, devices and systems while applying engineering principles for useful applications. Valuable insight gained on the functions of biological systems will further improve the design capacity. The advance of SB is expected to provide solutions to ...

Strategies to Combat Antibiotic Resistance

Antibiotic perturbation of the preterm infant gut microbiome and resistome.

The gut microbiota plays important roles in nutrient absorption, immune system development, and pathogen colonization resistance. Perturbations early in life may be detrimental to host health in the short and the long-term. Antibiotics are among the many factors that influence the development of the microbiota. Because antibiotics are heavily administered during the first critical years of gut ...